Program

24 September, 2014 - WEDNESDAY

Venue: MAIN BUILDING OF HUNGARIAN ACADEMY OF SCIENCES
(H-1051 Budapest, Széchenyi István tér 9.)
14.00 OPENING CEREMONY Chairs: K. Gyires, B. Sperlagh, Zs. Helyes, L. Vécsei, S. Szabo, P. Ferdinandy, P. Mátyus
14:40-18:20 STATE OF ART LECTURES OF TISSUE INJURY AND REPAIR Chairs: K.D. Rainsford - S. Szabo
14:40-15:10 NEW & OLD CONCEPTS OF CELL DEATH & TISSUE INJURY: NECROSIS, APOPTOSIS & NECROPTOSIS S. Szabo, X. Deng, X. Xiong, Zs.Sandor, J-H. Kim Departments of Pathology & Pharmacology, University of California-Irvine & VA Med. Center, Long Beach, CA, USA
15.10-15:40 GASTRO-INTESTINAL ADVERSE REACTIONS FROM NSAIDs: AN ONGOING ISSUE K. D. Rainsford Biomedical Research Centre, Sheffield Hallam University, Sheffield, England
15:40-16:10 EXPLOITING HYDROGEN SULFIDE IN DRUG DESIGN FOR GASTROENTEROLOGY J. L. Wallace University of Toronto, Toronto, Ontario, Canada
16:10-16:40 IN VIVO MOLECULAR IMAGING AND REAL TIME ASSESSMENT OF GASTRIC MUCOSAL INJURY AND PROTECTION USING CONFOCAL LASER ENDOMICROSCOPY: FOCUS ON MUCOSAL MICROVESSELS & PROGENITOR CELLS A.S. Tarnawski, A. Ahluwalia, M.K. Jones, H.M. Gergely VALBHS & SCIRE, Long Beach, CA, and the University of California, Irvine, CA, USA
16:40-17:00 BREAK
17:00-17:20 DISCOVERYAND MECHANISM OF GASTROPROTECTIVE ACTION OF CAPSAICIN J. Szolcsányi 1st Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary
17:20-17:50 COMMENSAL INTESTINAL MICROBIOTA: PROTECTION OF GUT AND BRAIN P. Holzer Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
17:50-18:20 ROLE OF NONSYNAPTIC GLUN2B-CONTAINING NMDA RECEPTORS IN EXCITOTOXICITY: EVIDENCE THAT FLUOXETINE SELECTIVELY INHIBITS THESE RECEPTORS AND MAY HAVE NEUROPROTECTIVE EFFECTS E. S. Vizi Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
18:30-20:30 WELCOME RECEPTION Venue: Hungarian Academy of Sciences

25 SEPTEMBER, 2014 - THURSDAY

Venue: HOTEL GELLÉRT – GOBELIN ROOM
(H-1111 Budapest, Szent Gellért tér 1.)
08:30-10:30 MORNING SESSION I.
INJURY/PROTECTION OF GASTROINTESTINAL MUCOSA 1. Chairs: T. Brzozowski – A. Tarnawski and J. Wallace
08:30-09:00 ROLE OF CARBON MONOXIDE IN GASTROPROTECTION AGAINST ACUTE GASTRIC MUCOSAL LESIONS T. Brzozowski, K. Jasnos, M. Magierowski, R. Pajdo, S. Kwiecien Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
09:00-09:30 NEUROGENIC MUCOSAL BICARBONATE SECRETION MEDIATED BY PURINERGIC P2Y RECEPTORS IN GUINEA-PIG DUODENUM J. D. Wood, G. Fei, X. Fang, G.D. Wang, S. Liu, X.Y. Wang Department of Physiology and Cell Biology
The Ohio State University College of Medicine, Columbus, Ohio, USA
09:30-10:00 GENDER DIFFERENCE IN DUODENAL HCO3- RESPONSE TO MUCOSAL ACIDIFICATION: IMPORTANCE OF UP-REGULATION OF ASICS3 BY ESTRADIOL K. Takeuchi1,2, Y. Ohashi1, E. Aihara2 1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan
2General Incorporated Association, Kyoto Research Center for Gastrointestinal Diseases, Kyoto, Japan
10:00-10:15 PROTECTIVE ROLES OF THE TRANSIENT RECEPTOR ANKYIRIN 1 ION CHANNEL IN A MOUSE COLITIS MODEL J. Kun1,2, I. Szitter1,2, Á. Kemény1,2, A. Perkecz1, L. Kereskai3, K. Pohóczky1, Á. Vincze4, Sz. Gódi4, I. Szabo4, J. Szolcsányi1, E. Pintér1,2, Zs. Helyes1,2 1Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary
2János Szentágothai Research Center, University of Pécs, Pécs, Hungary
3Department of Pathology, Medical School, University of Pécs, Pécs, Hungary
41st Department of Internal Medicine, Medical School, University of Pécs, Pécs, Hungary
10:15-10:30 HARKÁNY MEDICINAL WATER DRINKING ATTENUATES DEXTRAN-SULFATE-SODIUM-INDUCED COLITIS IN MICE G. Pozsgai1, R. Benkó1, L. Barthó1, K. Horváth2, E. Pintér1 1Department of Pharmacology and Pharmacotherapy, University of Pécs, Pécs, Hungary
2Zsigmondy Vilmos Harkány Medicinal Spa Hospital, Harkány, Hungary
10:30-11:00 COFFEE BREAK
11:00-13:00 Morning Session II.
INJURY/PROTECTION OF GASTROINTESTINAL MUCOSA 2. Chairs: P. Holzer – Gy. Mózsik and M. Nakamura
11:00-11:20 HEME OXYGENASE-1 EXPRESSED MACROPHAGES INHIBIT INTESTINAL INFLAMMATION Y. Naito, Y. Higashimura, K. Mizushima, K. Katada, and T. Takagi Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
11:20-11:40 THE COLONIC ION TRANSPORT AND MUCUS SECRETION DURING TREATMENT WITH BROAD SPECTRUM ANTIBIOTIC CEFTRIAXONE T. Dovbynchuk, A. Dranitsina, T. Chervinska, L. Zakordonets*, T. Beregova, L. Ostapchenko, G. Tolstanova Taras Shevchenko National University of Kiev; *Bogomolets National Medical University, Kiev, Ukraine
11:40-12:10 SIGNIFICANCE OF SUBSTANCE P IN GASTRIC, HEPATIC AND PULMONARY MALT LYMPHOMA INDUCED BY HELICOBACTER HEILMANNII INFECTION M. Nakamura1, H. Matsui2, A. Øverby1, T. Takahashi1 1School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
2Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
12:10-12:30 CENTRALLY-INITIATED GASTROPROTECTION: SIMILAR AND DISTINCT MECHANISMS K. Gyires and Z. Zádori Department of Pharmacology and Pharmacotherapy, Semmelweis University, Faculty of Medicine, Budapest, Hungary
12:30-13:30 LUNCH BREAK
13:30-14:30 POSTER SESSION I. (1-14) Chairs: Zs. Helyes - E. Pintér and A. Y. Sklyarov
14:30-16:20 AFTERNOON SESSION I.
CARDIOPROTECTION AND NEW TARGET OF OBESITY TREATMENT Chairs: P. Ferdinandy - R. Schulz
14:30-15:00 MITOCHONDRIAL PROTEINS IN CARDIOPROTECTION R. Schulz Institute of Physiology, Justus-Liebig University Giessen, Germany
15:00-15:30 ROLE OF THE ENDOCANNABINOID SYSTEM IN CARDIOVASCULAR INJURY AND INFLAMMATION P. Pacher NIH/NIAAA/DICBR Laboratory Physiological Studies, Section Oxidative Stress Tissue Injury, Bethesda
15:30-15:50 EXTRACELLULAR VESICLES IN CARDIOPROTECTION Z. Giricz Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest
15:50-16:20 THE ROLE OF VAGUS NERVE IN THE BRAIN-GUT AXIS: A TARGET FOR OBESITY TREATMENT H. Johannessen1, D. Revesz2, Y. Kodama1, N. Cassie3, K. P. Skibicka4, M. K. Olsen1, R. Lyle5, P. Barrett3, S. L. Dickson4, J. J. Holst6, J. F. Rehfeld7, K. Takeuchi8, B. Kulseng9, T. Thorlin2, E. Ben-Menachem2, C-M. Zhao1, D. Chen1,9 1Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
2Department of Clinical Neuroscience and Rehabilitation, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
3Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, Scotland 4Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
5Department of Medical Genetics Ullevål, Oslo University Hospital, Oslo, Norway
6Department of Biomedical Sciences, the Panum Institute, University of Copenhagen, Copenhagen, Denmark
7Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
8Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
9Department of Surgery, St. Olav’s University Hospital, Trondheim, Norway
16:20 -16:40 COFFEE BREAK
16:40-18:30 AFTERNOON SESSION II.
NSAIDS AND GASTROINTESTINAL TRACT Chairs: D. Chen, K. Gyires, K. Takeuchi
16:40-17:10 SMOOTH MUSCLE RELAXATION BY IBUPROFEN AND DICLOFENAC: IN VITRO MODELS REVEAL DIFFERENCES IN THEIR MODES OF ACTION B.A. Callingham1, R.L. Gilliver1, S. Jaker1, A.S. Milton1, K.D. Rainsford2 1Department of Pharmacology, University of Cambridge, Cambridge, UK 2Biomedical Res Centre, Sheffield Hallam University, Sheffield, UK
17:10-17:30 EFFECT OF MUCOSAL PROTECTIVE AGENTS ON EXACERBATION OF NSAID-INDUCED SMALL INTESTINAL LESIONS CAUSED BY ANTISECRETORY DRUGS IN RATS H. Satoh, K. Amagase, K. Takeuchi Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan
17:30-17:50 HUMAN PHASE I. STUDY OF ORALLY GIVEN CAPSAICINOIDS ALONE AND COMBINATION WITH DICLOFENAC: PHARMACOKINETIC ANALYSES OF CAPSAICINOIDS AND DICLOFENAC AND THEIR INHIBITORY ACTIONS ON PLATELET AGGREGATION IN HEALTHY MALES Gy. Mózsik1, T. Past1, A. Cziraki2, J. Szolcsányi3, M. Szalai4 1First Department of Medicine
2Instute of Cardiology
3Department of Pharmacology and Pharmacotherapy, Medical and Health Centre, University of Pécs, Hungary
4PannonPharma Pharmaceutical Ltd., Pécsvárad, Hungary
17:50-18:10 DYSFUNCTION OF MUCOSAL DEFENSE SYSTEM AND SECONDARY LOCAL ATTACK FACTORS T. Tomita1,4, H. Sadakata1,4, M. Tamura2, T. Kaneko3, Yumiko Nagano3, Hirofumi Matsui3 1Graduate School of Pure And Applied Sciences, University of Tsukuba, Ten-nohdai, Tsukuba, Japan
2Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ten-nohdai, Tsukuba, Japan
3Division of clinical medicine, Faculty of medical sciences, University of Tsukuba, Ten-nohdai, Tsukuba, Japan
4Timelapse Vision INC., Honcho, Asaka, Japan
18:10-18:30 PECULARITIES OF THE CHANGES OF NO-SYNTHASE/ARGINASE SYSTEM IN DIGESTIVE ORGANS UNDER THE CONDITIONS OF STRESS AND COX-1/COX-2, COX-2/5-LOX BLOCKAGE I.S. Fomenko, N.B. Panasyuk, I.I. Ilkiv, T.I.Bondarchuk, P. A. Sklyarov, V.Y. Yemelyanenko, N.V. Denisenko, L.P. Biletska, A. Y. Sklyarov Danylo Halytsky Lviv National Medical University, Ukraine
20:00 ORGAN CONCERT

26 SEPTEMBER, 2014 – FRIDAY

Venue: HOTEL GELLÉRT – GOBELIN ROOM
(H-1111 Budapest, Szent Gellért tér 1.)
08:30-10:10 MORNING SESSION III.
INJURY/PROTECTION OF GASTROINTESTINAL MUCOSA 3. Chairs: L. Filaretova - H. Satoh and P. Sikiric
08:30-09:00 ROLE OF CORTRICOTROPIN-RELEASING FACTOR RECEPTOR TYPE 1 AND 2 SIGNALING PATHWAYS IN GASTROPROTECTION AGAINST ACUTE GASTRIC MUCOSAL INJURY L.P. Filaretova, M.A. Mayzina, T.R. Bagaeva, O.Yu. Morozova Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, St. Petersburg, Russia
09:00-09:30 STABLE GASTRIC PENTADECAPEPTIDE BPC 157 - CURRENT STATUS P. Sikiric, S. Seiwerth, B. Turkovic, R. Rucman, D. Drmic, J. Suran, M. Sever, R. Klicek Department of Pharmacology, Department of Pathology Medical Faculty University of Zagreb, Zagreb, Croatia
09:30-09:50 A NEW LOOK ON CHANGES IN NON-REFLUX ESOPHAGITIS VS NON-EROSIVE ESOPHAGITIS: ASSOCIATION OR CAUSALITY? O. Zayachkivska, N. Hrytcevych, Ch. Hrynivska, A, Yaschenko Lviv National Medical University, Lviv, Ukraine
09:50-10:10 HELICOBACTER PYLORI-INDUCED EXPRESSION OF MCP-1 AND iNOS IS MEDIATED WITH NADPH OXIDASE AND JAK2/STAT3 IN GASTRIC EPITHELIAL CELLS S.O. Cho, J.W. Lim, H. Kim Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul 120-749, Korea
10:10-10:40 COFFEE BREAK
10:40-13:00 MORNING SESSION IV.
NEUROPROTECTION Chairs: B. Sperlagh - L. Vécsei and P. Mátyus
10:40-11:10 NEURODEGENERATION AND KYNURENINES: NOVEL PREVENTIVE AND THERAPEUTIC POSSIBILITIES L. Vécsei Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary
11:10-11:40 NEUROPROTECTION IN FOCAL ISCHEMIA: FAILURES AND PERSPECTIVES L. Csiba Department of Neurology, Debrecen University, Debrecen, Hungary
11:40-12:00 NOVEL MULTITARGET DRUG DEVELOPMENT STRATEGIES TO COMBAT NEURODEGENERATION B. Sperlágh1, M. Baranyi1, F. Gölöncsér1, Sz. Kulcsár1, P. Mátyus2, ML Khoo3, P. Huleatt3, C.LL. Chai3 1Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
2Institute of Organic Chemistry, Semmelweis University, Budapest, Hungary
3Institute of Chemical and Engineering Sciences, A*STAR, Singapore
12:00-12:30 MODULATION OF WNT SIGNALING FOR NEUROPROTECTION P. L. R. Ee, P. Bahety, L. Zhang, W. Ong Department of Pharmacy, National University of Singapore, Singapore
12:30-13:00 HONORARY MEMBERSHIP-LECTURE
CYTOPROTECTIVE EFFECT OF INCRETINS IN ANIMAL MODELS OF DIABETES MELLITUS E. Adeghate1, M. Lotfy2, J. Singh3 1Department of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
2Biology Department, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates
3Schools of Pharmacy and Forensic and Investigative Sciences, University of Central Lancashire, Preston, United Kingdom
13:00-14:00 LUNCH BREAK
14:00-15:00 POSTER SESSION II. (15-29) Chairs: G. Varga - O. Zayachkivska
15:00-17:40 AFTERNOON SESSION 3.
GASTROINTESTINAL MALIGNANT DISEASES, REGENERATION, STEM CELLS Chairs: Ki Baik Hahm - A. Yanaka and J. Wood
15:00-15:30 ADAPTIVE CYTOPROTECTION AND CANCER CHEMOPROTECTION OF GI TRACT BY SULFORAPHANE VIA NRF2-DEPENDENT AND INDEPENDENT PATHWAYS A. Yanaka Hitachi Medical Education and Research Center, Faculty of Medicine, University of Tsukuba, Hitachi, Japan
15:30-16:00 DEVELOPMENT OF FLUORESCENCE-BASED CO-CULTURE WITH NORMAL AND CANCER CELLS AS AN INDICATOR FOR EVALUATION OF CANCER THERAPEUTIC EFFECTS H. Matsui, M. Tamura, I. Hyodo, J. Tanaka and Y. Miwa Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
16:00-16:30 FAT-1 TRANSGENIC MICE PRODUCING N-3 POLYUNSATURATED FATTY ACIDS SIGNIFICANTLY PREVENTED HELICOBACTER PYLORI-INDUCED GASTRIC CARCINOGENESIS; NOVEL CYTOPROTECTIVE MECHANISM OF OMEGA-3 FATTY ACID Ki Baik Hahm, Eun-Hee Kim, Young-Min Han CHA University Cancer Prevention Research Center and CHA University Bundang Medical Center, Seongnam, Korea
16:30-16:50 TRIPLE ROLES OF AUTOPHAGY IN CYTOPROTECTION, CELL DEATH AND TUMORIGENESIS WITH SPECIAL REFERENCE TO GASTRIC ECL CELLS C.M. Zhao and D. Chen Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
16:50-17:10 MESENCHYMAL STEM CELLS AS ANTIINFLAMMATORY AND TISSUE REGENERATION TOOLS G. Varga Department of Oral Biology, Semmelweis University, Budapest, Hungary
17:10 CLOSING OF THE SYMPOSIUM
20:00 FAREWELL PARTY (OPTIONAL)

POSTER PRESENTATIONS

Poster size (AO portrait): 841mm horizontally x 1189mm vertically

1 THE HISTAMINE H4 RECEPTOR: A NEW TARGET FOR GASTROSPARING ANTI-INFLAMMATORY DRUGS? M. Adami, G. Coruzzi Department of Neuroscience, University of Parma, 43125 Parma, Italy
2 DIFFERENCES BETWEEN ACUTE AND SUB ACUTE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) EXPERIMENTAL MODELS OF PARKINSON’S DISEASE (PD): QUANTIFICATION OF NEUROTRANSMITTERS AND ENDOCANNABINOIDS CHANGES IN MICE STRIATUM M. Baranyi, B. Sperlágh Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
3 IMPACT OF PRENATAL PROGRAMMING ON BROWN ADIPOSE TISSUE FORMATION L. Bezpalko, O. Zayachkivska Department of Physiology, Lviv National Medical University, Lviv, Ukraine
4 ACTION OF DIFFERENT NSAIDs ON PARAMETERS OF NO-SYNTHASE SYSTEM IN PANCREAS OF RATS UNDER CONDITION OF WATER IMMERSION RESTRAIN STRESS T.I. Bondarchuk, I.S. Fomenko, L.P. Biletska, N.B. Panasyuk, A.Y. Sklyarov Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
5 NOCICEPTIVE ROLE OF HEMOKININ-1, THE NEWEST MEMBER OF THE TACHYKININ FAMILY, IN CHRONIC TRAUMATIC NEUROPATHY MODEL OF THE MOUSE É. Borbély1,2, V. Tékus1,2, Zs. Hajna1,2, Á. Hunyady1, A. Berger3, C.J. Paige3, J. Szolcsányi1, E. Pintér1,2, Zs. Helyes1,2 1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Pécs, Hungary
2János Szentágothai Research Center, Pécs, Hungary
3Ontario Cancer Institute, University Health Network, Toronto, Canada
6 PEPTIDERGIC SENSORY NERVES ARE IMPORTANT REGULATORS IN EXPERIMENTAL IMMUNE ARTHRITIS B. Botz1,2, É. Borbély1,2, T. Kenyér1,2, K. Bölcskei1,2, T. Kiss1,2, T. Németh3, M. Kovács3, A. Mócsai3, J. Szolcsányi2, E. Pintér1,2, Zs. Helyes1,2 1University of Pécs, School of Medicine, Department of Pharmacology and Pharmacotherapy, Pécs, Hungary,
2University of Pécs, János Szentágothai Research Centre, Molecular Pharmacology Research Team, Pécs, Hungary,
3Semmelweis University, Department of Physiology, Budapest, Hungary
7 ANTIHYPERALGESIC EFFECT OF CHRONIC MONOAMINE OXYDASE (MAO)-B INHIBITOR TREATMENT IN A TRAUMATIC MONONEUROPATHY MODEL IN MICE K. Bölcskei1,2, V. Tékus1,2, R. Deme3, P. Mátyus3, Zs. Helyes1,2 1Department of Pharmacology and Pharmacotherapy, University of Pécs, Pécs, Hungary
2János Szentágothai Research Centre, University of Pécs, Pécs, Hungary
3Department of Organic Chemistry, Semmelweis University, Budapest, Hungary
8 ANIMAL MODEL OF NON-REFLUX ESOPHAGITIS VIA NSAID-INDUCED INJURY AND MODIFICATION BIOSYNTHESIS OF HYDROGEN SULFIDE N. Bula, E. Gavriluk, O. Zayachkivska Lviv National Medical University, Lviv, Ukraine
9 EXPRESSION OF TRANSIENT RECEPTOR POTENTIAL VANILLOID 1, 4 (TRPV1, TRPV4) AND ANKYRIN 1 (TRPA1) ION CHANNELS IN THE HUMAN GASTRIC MUCOSA K. Csekő2, B. Szalontai2, K. Pohóczky1,2, I. Hegedűs4, A. Perkecz1, A. Illés3, Á. Vincze3, J. Czimmer3, Zs. Helyes1, I. L. Szabo3 1Department of Pharmacology and Pharmacotherapy, University of Pécs, Hungary
2Szentagothai Research Centre, University of Pécs, Hungary
3First Department of Internal Medicine, Medical and Health Center, University of Pécs, Hungary
4Department of Pathology, University of Pécs, Hungary
10 CELECOXIB INDUCED GASTROINTESTINAL, LIVER AND BRAIN LESIONS IN RATS, COUNTERACTION BY STABLE GASTRIC PENTADECAPEPTIDE BPC 157 OR L-ARGININE, AGGRAVATION BY L-NAME D. Drmic, D. Kolenc, A. Zenko Sever, M. Sever, J. Suran, R. Klicek, S. Ilic, L. Brcic, S. Seiwerth, P. Sikiric Department of Pharmacology, Department of Pathology, Medical Faculty, University of Zagreb, Zagreb, Croatia
11 ACTION OF H2S–RELEASING NSAIDs ON THE PARAMETERS OF NITRIC OXIDE SYSTEM IN GASTRIC MUCOSA OF RATS UNDER STRESS CONDITIONS I.S. Fomenko, A.Ya. Sklyarov Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
12 CYTOPROTECTIVE EFFECT OF (-)-DEPRENYL H. Kalasz1, E. Adeghate2 and K. Tekes3 1Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
2Department of Anatomy, United Arab Emirates University, Al Ain, UAE
3Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
13 INVOLVEMENT OF REACTIVE OXYGEN SPECIES IN β-CATENIN SIGNALING IN GASTRIC CANCER CELLS M.J. Kim, J.W. Lim, H. Kim Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul 120-749, Korea
14 BENEFICIAL EFFECT OF PENTADECAPEPTIDE BPC 157 ON THE FISTULAS HEALING IN GI TRACT R. Klicek, M. Sever, G. Aralica, L. Brcic, S. Skorjanec, M. Baric, V. Cesarec, D. Vukusic, A. Zenko Sever, T. Grgic, D. Kolenc, S. Seiwerth, P. Sikiric Department of Pharmacology and Department of Pathology, Medical Faculty, University of Zagreb, Zagreb, Croatia
15 THE EFFECT MESENCHYMAL STEM CELLS OF DENTAL PULP ORIGIN ON OSSEOINTEGRATION OF MINI IMPLANTS INTO RAT TAIL VERTEBRAE K. Kálló1, K. Perczel-Kovách1, B. Kerémi1, K. Nagy1, R. Rácz1, K.B. Csomó1, S. Farkasdi1, K. Kádár1, R. Varga2, J. Blazsek1, G. Varga1 1Department of Oral Biology, Semmelweis University, Budapest Hungary
2FULL-TECH Dental Implant Company, Hungary
16 UPREGULATION OF THE TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1 RECEPTOR IN THE INFLAMED HUMAN AND MOUSE COLON J. Kun1,2, I. Szitter1,2, Á. Kemény1,2, A. Perkecz1, L. Kereskai3, K. Pohóczky1, Á. Vincze4, Sz. Gódi4, I. Szabo4, J. Szolcsányi1, E. Pintér1,2, Zs. Helyes1,2 1Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary
2János Szentágothai Research Center, University of Pécs, Pécs, Hungary
3Department of Pathology, Medical School, University of Pécs, Pécs, Hungary
41st Department of Internal Medicine, Medical School, University of Pécs, Pécs, Hungary
17 CENTRAL CORTRICOTROPIN-RELEASING FACTOR ADMINISTRATION INDUCES PROTECTION AGAINST INDO-METHACIN-CAUSED GASTRIC INJURY THROUGH PARTICIPATION OF GLUCOCORTICOIDS M.A. Mayzina, T.R. Bagaeva, L.P. Filaretova Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology,
St. Petersburg, Russia
18 REACTIVE OXYGEN AND NITROGEN SPECIES ACCELERATED TUMORIGENESIS Y. Nagano1,2, H. Matsui1, Y. Nakamura2, I. Hyodo1 1The Graduate School of Comprehensive Human Sciences, University of Tsukuba
2Cell Engineering Division, RIKEN BioResource Center
19 INVOLVEMENT OF STAT3 SIGNALING IN PROLIFERATION OF PANCREATIC CANCER CELLS M. Park, J.W. Lim, H. Kim Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul 120-749, Korea
20 DUAL ROLE OF GASTIC ACID IN CYTOPROTECTION ON EXTRAGASTRAL DAMAGE MANIFESTATION I. Pshyk-Titko, O. Zayachkivska, A. Yashchenko Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
21 INFLUENCE OF MULTIPROBIOTIC ON AGE RELATED CHANGES IN GASTRIC SECRETION AND TRANSPORT OF WATER AND ELECTROLYTES ACROSS THE EPITHELIUM OF RATS COLON N.S.Skochko, T.V. Beregova, E.A. Torgalo Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
22 EXPERIMENTAL EVIDENCE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS EFFICACY IN THE CHRONIC PANCREATITIS TREATMENT S. Sukhodolya1, V. Petrushenko1, T. Falalyeyeva2, T. Beregova2 1National Pirogov Memorial Medical University, Vinnitsa, Ukraine
2Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
23 GALANIN 3 RECEPTOR MEDIATES CHRONIC CIGARETTE SMOKE-INDUCED STRUCTURAL AND FUNCTIONAL ALTERATIONS IN THE MOUSE LUNG I. Szitter1,2, S. Brunner3, B. Kofler3, T. Kiss1,2, A. Perkecz1, D. Feller1, Zs. Helyes1,2 1University of Pécs, Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, Pécs, Hungary
2Szentágothai János Research Center, Pécs, Hungary
3Universitätsklinik für Kinder- und Jugendheilkunde, Paracelsus Medizinische Privatuniversität, Salzburg, Austria
24 A SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) INHIBITOR HAS AN ANTAGONISTIC ACTION ON TRP ION CHANNELS ON PRIMARY SENSORY NEURONS É. Szőke1, É. Sághy1, M. Payrits1, P. Mátyus2, R. Deme2, Zs. Helyes1 1Department of Pharmacology and Pharmacotherapy, Szentágothai Research Center, University of Pécs, Pécs, Hungary
2Department of Organic Chemistry, University of Semmelweis, Budapest, Hungary
25 LUBIPROSTONE PREVENTS NSAID-INDUCED SMALL INTESTINAL DAMAGE BY SUPPRESSING THE EXPRESSION OF INFLAMMATORY MEDIATORS VIA EP4 RECEPTORS K. Takeuchi1,2, S. Hayashi1,3, K. Amagase1 1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan
2General Incorporated Association, Kyoto Research Center for Gastrointestinal Diseases, Kyoto 604-8106, Japan
3Division of Gastrointestinal Pathophysiology, Department of Biosciences, Institute of Natural Medicine, University of Toyama
26 PHENOLIC COMPONENTS OF DATE FRUITS POSSESSING ANTIOXIDANT ACTIVITY K. Tekes1, S. Antus2, H. Kalász1, E. Adeghate3, É. Szőke1, L. Kursinszki1, K. Gulácsi2, A. Kiss-Szikszai2, A. Adem3 1Semmelweis University, Budapest, Hungary
2University of Debrecen, Debrecen, Hungary
3United Arab Emirates University, Al Ain, UAE
27 THE LATERAL HYPOTHALAMUS IS INVOLVED IN THE GASTRO PROTECTIVE EFFECT OF ANGIOTENSIN II AND 2-ARACHIDONOYL GLYCEROL V.E. Tóth, Á. Fehér, Z.S. Zádori, K. Gyires Department of Pharmacology and Pharmacotherapy, Semmelweis University, Faculty of Medicine, Budapest, Hungary
28 SOMATIC PAIN SENSITIVITY UNDER THE CIRCUMSTANCES OF INDOMETACIN-INDUCED GASTRIC AND SMALL INTESTINAL INJURY IN RATS N.I. Yarushkina, T.R. Bagaeva, L.P. Filaretova Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology,
St. Petersburg, Russia
29 ALPHA2-ADRENOCEPTORS AND IMIDAZOLINE RECEPTORS IN THE REGULATION OF GASTROINTESINAL FUNCTIONS Z.S. Zádori, V.E. Tóth, Á. Fehér, K. Gyires Department of Pharmacology and Pharmacotherapy, Semmelweis University, Faculty of Medicine, Budapest, Hungary